One & Two Discovery Square

An exclusive collaboration between Mayo Clinic’s partner companies, higher education, and startups. Only 495 steps away from the main Mayo Clinic Campus.

Discovery Square Innovation District is a connected district that brings researchers, clinicians, entrepreneurs, and industry partners into close proximity with Mayo Clinic.
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One and Two Discovery Square are within 495 steps of the Mayo Clinic Campus and seven of Mayo Clinic’s research buildings

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Plummer Building
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Hilton Building
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Guggenheim Building
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Kellen Building
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Opus Medical Imaging Building
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Medical Science Building
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Stabile Building

Building Types

Patient care
Research buildings
Patient care and research

Working with Mortenson, the development of One and Two Discovery Square is the anchor of the Discovery Square sub-district.
Created for collaboration, with access to Mayo Clinic’s Core Facilities – a mere 495 steps from Mayo Clinic’s state of the art research and lab space (infrastructure for wet and dry labs and GMP facilities).


One and Two Discovery Square feature advanced labs, collaborative team spaces, casual seating areas, multiple shared conference rooms and a spacious courtyard for teams to ideate, collaborate, reflect and relax. Mortensen Construction referred to it as “structured serendipity” between tenants and the broader medical community in Rochester. 

Current Tenants of
One and Two Discovery Square

“The Destination Medical Center will transcend the previously established limits of how we define access to health and wellness.”

— Andre Terzic, M.D., Ph.D.

Former Director, Center for Regenerative Biotherapeutics, Mayo Clinic

STATE OF MINNESOTA

OLMSTED COUNTY

CITY OF ROCHESTER

MAYO CLINIC

DMC

Create a comprehensive strategic plan for the entire region. Leverage public investment to attract private investment to Rochester. Create more than 30,000 jobs with workforce development strategies. Generate additional net tax revenue; $7.5-8.0 billion in the next 35 years. Become the Destination for Health and Wellness, now and in the future. DMC can also work as a conduit to Mayo Clinic for companies coming to Rochester.

FUNDING – A BALANCE OF PUBLIC & PRIVATE

Public

Private

“It is a great thing to make scientific discoveries of rare value, but it is even greater to be willing to share these discoveries and to encourage other workers in the same field of scientific research.”

— Dr. William J. Mayo, M.D.


Working with Mayo Clinic

Mayo Clinic has a history of changing the industry through cutting-edge innovation and is credited with many important medical contributions such as the creation of laboratory medicine and the health record. This firsthand understanding of the value of bringing new ideas to market is the reason the Clinic established a model for innovation and collaboration with industry to drive new treatments and cures to benefit patients at scale, fast. There are many ways to partner and collaborate with the Clinic, let DMC help you navigate the “front doors”:

Mayo Clinic Corporate Development
Front door to businesses seeking strategic partnerships.


Mayo Clinic Ventures
Technology transfer arm of Mayo Clinic.


Mayo Clinic Innovation Exchange
Mayo Clinic’s technology collaboration portal.


Mayo Clinic Platform
The health tech and AI engine of Mayo Clinic.


Mayo Clinic Center for Regenerative Biotherapeutics
The biopharmaceutical and cellular therapy development center.


Mayo Clinic Advanced Diagnostics
Diagnostics Laboratory Space designed to pioneer patient treatments and diagnostics.


This is what it means to collaborate with Mayo Clinic.
Destination Medical Center is the conduit providing access to the highest level of medical skill in the world.

$1.1B+ In annual research funding ($420M Mayo / $680M external) 6.5 Months on average faster FDA PMAs compared to the U.S. as a whole † 137 Countries represented in the 1.3 million patients annually treated #1 Recognized as the best hospital in the world* 1.3M Patients treated annually within the Mayo Clinic network 8,700 Patents filed since its start 3,500 Patents issued 40 Specialty labs within nine divisions #1 In invention disclosures and licenses** #1 In human, new device (non-diagnostic), digital leveraging AI & EMR ‡ 300+ Companies and startups involving the Mayo Clinic 4,000 Licensed technologies since inception 30 Days shorter 510K clearances with collaborating with
Mayo Clinic
8,000 Physicians and clinical residents on staff 22M Laboratory tests performed each year in the Mayo Clinic's Department of Laboratory Medicine and Pathology in Rochester My Brother and I sculpture of the Mayo brothers William and Charles, by Tuck Langford. Installed in 2002 at the entrance of the Mayo Clinic.

*Newsweek, **Becker’s Hospital Review, †LifeScience Alley, ‡Mayo Clinic

The “Medical Alley” Corridor


The region was given this name due to the high concentration of MedTech and Life Science companies located here, along with the presence of major research institutions at Mayo Clinic and the University of Minnesota. The Medical Alley geography is home to more than 15,000 companies in the MedTech and Life Sciences industries, employing more than 500,000 people.

Rochester, MNMedical Alley geographic area
60-minute drive-time population1,085,8284,271,269
60-minute drive-time population working in healthcare industry100,186
(20%)
405,345
(18%)
Percent of working population in healthcare industry51%18%

Notable Life Science Companies in Rochester

Cytotheryx is a platform technology company focused on the development of a high-quality, consistent source of primary human hepatocytes (HHCs), or liver cells.

End-to-end contract development and manufacturing organization (CDMO) partner building robust and reliable supply chains for targeted radiotherapies.

Endomicroscopic digital imaging technology offers real-time, 3D imaging at the single-cell level, in a non-destructive manner enabling clinicians to make immediate decisions.

A preclinical, biotherapeutic company developing a cell-based bioartificial liver system, the Spheroid Reservoir Bioartificial Liver (SRBAL), to treat acute liver failure (ALF).

Developing novel, life-extending technologies and expanding the availability of transplantable organs for patients dealing with a variety of lung and arterial diseases.

Developing the next generation of targeted genetic therapies by engineering viruses, viral vectors and viral envelope glycoproteins to deliver gene therapies directly to targeted cells.

Seeking to change regenerative medicine by utilizing exosome technology to improve the lives of more patients, in more places, across more diseases, from every walk of life.


With shovels in the ground and more than $5 billion of investment committed, Rochester is America’s City for Health. Become a part of it. Contact a member of DMC’s Business Development team below.

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Michael Flynn
Senior Director of Economic Development
[email protected]

Chris Schad
Director of Business Development
[email protected]

Kylle Jordan
Business Development Manager
[email protected]

Uddam Chea
Business Analyst
[email protected]

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    Contact