One & Two Discovery Square
An exclusive collaboration between Mayo Clinic’s partner companies, higher education, and startups. Only 495 steps away from the main Mayo Clinic Campus.
Discovery Square Innovation District is a connected district that brings researchers, clinicians, entrepreneurs, and industry partners into close proximity with Mayo Clinic.
Discovery Square Innovation District is a new address for the future of biomedical, research, education, and technology innovation, Discovery Square is the keystone to the Destination Medical Center (DMC) economic development strategy.
One and Two Discovery Square are within 495 steps of the Mayo Clinic Campus and seven of Mayo Clinic’s research buildings
Building Types

Working with Mortenson, the development of One and Two Discovery Square is the anchor of the Discovery Square sub-district.
Created for collaboration, with access to Mayo Clinic’s Core Facilities – a mere 495 steps from Mayo Clinic’s state of the art research and lab space (infrastructure for wet and dry labs and GMP facilities).
One and Two Discovery Square feature advanced labs, collaborative team spaces, casual seating areas, multiple shared conference rooms and a spacious courtyard for teams to ideate, collaborate, reflect and relax. Mortensen Construction referred to it as “structured serendipity” between tenants and the broader medical community in Rochester.

Current Tenants of
One and Two Discovery Square
“The Destination Medical Center will transcend the previously established limits of how we define access to health and wellness.”
— Andre Terzic, M.D., Ph.D.
Former Director, Center for Regenerative Biotherapeutics, Mayo Clinic
“It is a great thing to make scientific discoveries of rare value, but it is even greater to be willing to share these discoveries and to encourage other workers in the same field of scientific research.”
— Dr. William J. Mayo, M.D.
Working with Mayo Clinic
Mayo Clinic has a history of changing the industry through cutting-edge innovation and is credited with many important medical contributions such as the creation of laboratory medicine and the health record. This firsthand understanding of the value of bringing new ideas to market is the reason the Clinic established a model for innovation and collaboration with industry to drive new treatments and cures to benefit patients at scale, fast. There are many ways to partner and collaborate with the Clinic, let DMC help you navigate the “front doors”:
Mayo Clinic Corporate Development
Front door to businesses seeking strategic partnerships.
Who it’s for:
Partnerships and strategic collaborations. Mergers and acquisitions and investing.
Mayo Clinic Ventures
Technology transfer arm of Mayo Clinic.
Who it’s for:
Advances technologies, evaluates and protects intellectual properties including licensing and management.
Mayo Clinic Innovation Exchange
Mayo Clinic’s technology collaboration portal.
Who it’s for:
Developing technology where a relationship with a Mayo Clinic innovator or clinician is beneficial (education, networking, advice, and introductions).
Mayo Clinic Platform
The health tech and AI engine of Mayo Clinic.
Who it’s for:
Connecting companies developing life changing innovations with Mayo Clinic’s rich, de-identified datasets.
Mayo Clinic Center for Regenerative Biotherapeutics
The biopharmaceutical and cellular therapy development center.
Who it’s for:
Developing new cellular therapies or technologies for biomanufacturing processes.
Mayo Clinic Advanced Diagnostics
Diagnostics Laboratory Space designed to pioneer patient treatments and diagnostics.
Who it’s for:
Developing tools that are better, faster, or cheaper than what’s currently existing.

This is what it means to collaborate with Mayo Clinic.
Destination Medical Center is the conduit providing access to the highest level of medical skill in the world.
*Newsweek, **Becker’s Hospital Review, †LifeScience Alley, ‡Mayo Clinic

The “Medical Alley” Corridor
The region was given this name due to the high concentration of MedTech and Life Science companies located here, along with the presence of major research institutions at Mayo Clinic and the University of Minnesota. The Medical Alley geography is home to more than 15,000 companies in the MedTech and Life Sciences industries, employing more than 500,000 people.
| Rochester, MN | Medical Alley geographic area | |
|---|---|---|
| 60-minute drive-time population | 1,085,828 | 4,271,269 |
| 60-minute drive-time population working in healthcare industry | 100,186 (20%) | 405,345 (18%) |
| Percent of working population in healthcare industry | 51% | 18% |
Notable companies residing within the Medical Alley geography

Notable Life Science Companies in Rochester
With shovels in the ground and more than $5 billion of investment committed, Rochester is America’s City for Health. Become a part of it. Contact a member of DMC’s Business Development team below.

Michael Flynn
Senior Director of Economic Development
[email protected]

Geof Hannigan
Director of Startup Engagement
[email protected]

Kylle Jordan
Innovation Ecosystem Development Senior Manager
[email protected]

Putheawin Samphea
Business Development Operations Coordinator
[email protected]
Let’s discuss your opportunity!

